Kromasil AmyCoat

AmyCoat

analysis

You are working with HPLC for the separation and identification of analytical substances in laboratories. Challenge the selectivity of Kromasil for your most sensitive analysis.

development

You need to quickly purify substances for further studies in the development of pharmaceuticals. Kromasil will help you achieve your goals with ease and efficiency.

You are using preparative chromatography for high efficiency purification in a pilot or up to industrial-scale production. The robustness of Kromasil is available in ton quantities to meet your process demands.

Loadability of Kromasil AmyCoat

Preparative applications.

“Works all the way”

Kromasil products are well known for their ability to work along the whole spectrum from analytical to industrial scale chromatography.

Examples:

Carbinoxamine

Analytical injection
Eluent:
heptane/2-propanol/DEA (90/10/0.1)
Sample size: 10 µg
Detection: UV 254 nm

Preparative injection
Eluent:
heptane/2-propanol/DEA (90/10/0.1)
Sample size: 7.5 mg
Detection: UV 280 nm

	Enantiomer 1	Enantiomer 2
Purity [%]	100	99.7
Yield [%]	99.7	100

Common conditions:
Phase: Kromasil AmyCoat, 10 µm
Flow rate: 0.7 ml/min
Column size: 4.6×250 mm
Temperature: 25 °C

Equivalent loading on a
50×250 mm column:
900 mg

Warfarin

Preparative injection of Warfarin on AmyCoat

Analytical injection
Eluent:
heptane/2-propanol (85/15)
Sample size: 8.5 µg
Detection: UV 230 nm

Preparative injection
Eluent:
heptane/2-propanol (85/15)
Sample size: 17.1 mg
Detection: UV 325 nm

	Enantiomer 1	Enantiomer 2
Purity [%]	99.7	99.5
Yield [%]	99.4	99.7

Common conditions:
Phase: Kromasil AmyCoat, 10 µm
Flow rate: 1 ml/min
Column size: 4.6×250 mm
Temperature: 25 °C

Equivalent loading on a
50×250 mm column:
2.0 g

· Eka Chemicals, Separation Products · SE–445 80 Bohus, Sweden · Phone +46 31 58 70 00 · Fax +46 31 58 77 27 ·
· E-mail kromasil@eka.com ·