Kromasil Chiral technical evidence

• Bonded phases - Introduction
• Bonded phases - Mechanical and chemical stability
• Bonded phases - Loadability
• Coated phases - Introduction
• Coated phases - Mechanical stability
• Coated phases - Performance stability
• Coated phases - Loadability

Mechanical and chemical stability of Kromasil Chiral bonded phases

In large diameter columns, the mechanical stability of the stationary phase is of great importance.

Fig. 1 - Kromasil Chiral with different purging solvents.

“Kromasil silica is among the most mechanically stable HPLC silicas.”

The high chemical stability is given by the nature of the network polymer covalently bonded to the silica. Kromasil Chiral can be used with most solvents and buffers in the mobile phase without degradation, see figure 1. TFA buffers can under certain conditions cause some hydrolysis of the phases.

Kromasil Chiral have already been used in DAC columns for more than 20,000 preparative injections without any deterioration.