Various separation methods are available for the production of pharmaceutical drugs, such as crystallization, distillation, and, of course, HPLC. Since time is such a critical factor in the development stage, HPLC is usually the method of choice, even if a different technique is finally used for production. This is due to the fact that an efficient HPLC separation, producing the desired amount of material, can usually be set up in a shorter time compared to the alternative methods, and productivity is high.
In other words, HPLC is often the most powerful technique available for producing a desired amount of substance with a high purity and yield, in the shortest possible time.