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Kromasil chiral technical evidence
Fig. 1 - Chiral polymer synthesis.
Fig. 2 - The binding of the chiral polymer to the Kromasil silica.
Kromasil bonded chiral phases: a network of chiral polymers covalently bonded to the Kromasil silica matrix
The silica
Kromasil chiral stationary phases for HPLC, SFC and SMB are based on the well-known Kromasil premium spherical silica. The surface properties of the silica have a great impact on the selectivity of the chiral phases.
The chiral polymer
Two phases have been developed to complement each other in selectivity:
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Kromasil Chiral DMB
: The chiral monomer is O,O'-bis (3,5-dimethylbenzoyl)-N,N'-diallyl-L-tartar diamide. -
Kromasil Chiral TBB
: The chiral monomer is O,O'-bis (4-tert-butylbenzoyl)-N,N'-diallyl-L-tartar diamide.
The chiral monomers are reacted with a multifunctional hydrosilane yielding a network polymer incorporating the bifunctional C2-symmetric chiral selector (figure 1).
The chiral stationary phases
The chiral polymer is covalently bonded to functionalized Kromasil silica, as seen in figure 2.
Performance
Kromasil Chiral separate a broad range of racemates (see separate application brochure). The phases are based on 5 §mu;m particles for best efficiency. The small particles are necessary for difficult separations and give sharp peaks in both analytical separations and semi-prep purification. The best selectivity is obtained under normal phase conditions. The phases are however stable also under reversed phase conditions.
“Chiral network polymers covalently bonded to Kroamsil silica to be used with all solvents in HPLC, SFC and SMB/MCC.”
Kromasil chiral bonded stationary phases are patented by Eka Chemicals AB and manufactured according to ISO 9001.
