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June 2021

Kromasil introduces a purification toolbox for GLP-1 agonists

With the number of people around the world diagnosed with diabetes increasing, the need for adequate treatments are also on the rise. Many of the substances used in production of this type of pharmaceuticals are peptides and have been found challenging to purify, in an efficient way, to the level needed to be approved for safe use by patients. This is where Kromasil's high performing chromatography media now supports the pharmaceutical industry.

“With our efficient purification strategy, it is possible to reach the 99.5 % purity needed for regulatory approval in only two steps compared to three or four steps, which is often the case in the industry today. This translates into greatly improved efficiency and productivity for our customers, said Patrick Wilhelm,” Vice President of Inorganic Specialties at Nouryon.

The new purification toolbox for GLP-1 (glucagon-like peptide-1) agonists such as liraglutide, enables tailor made solutions to the different conditions in our customers production processes and includes procedures that greatly improve the Kromasil media lifetime by increasing the number of purification cycles that can be carried out. This enables our customers to significantly reduce the time needed to optimize their purification process and as a result, a more efficient process.

“Type 2 diabetes patients rely on their medicine every day and, in many cases, it’s a lifelong treatment. We are proud to be able to provide our pharmaceutical customers with solutions that contribute to the promotion of well-being to ensure healthy lives,” said Wilhelm.

To learn more, download our brochure, listen to how our scientists talk about it or get in touch with us:

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July 2020

Kromasil wettable phase for analysis and prep HPLC

Kromasil C18(w) is a wettable HPLC phase specifically engineered for bio-separations as well as food and beverage analysis. The focus of this phase is for the analysis and purification of key biomolecules under initially aqueous conditions.

Kromasil C18(w) is part of the Kromasil Classic portfolio of perfectly spherical, totally porous silica media with 100 Å pore size. The phase, with its polar embedded end-capping, has different characteristics than the classic Kromasil C18, as is shown in the comparing Tanaka diagram. This allows for separations and analysis of samples that are naturally provided in aqueous conditions. The new wettable phase enables new selectivity and resolution opportunities to isolate impurities and enrich samples containing compounds such as amino acids and peptides. The chromatography can be run under RP conditions or in fully aqueous conditions if required.

The Kromasil wettable phase is now supplied in both 5 and 10 µm particles. Columns are available from 4.6 to 21.2 mm ID. The larger particles are also available as bulk for packing in DAC systems – even repeatedly, as the well-known mechanical stability of Kromasil packing media is also valid for this material.

Independently, if you work with analysis, development or screening, in pilot facilities or manufacturing, the flexibility and alternative selectivity offered by Kromasil C18(w) can be of significant benefit for your facility in view of the wider spectrum of polar compounds that are currently investigated and purified in pharma and biotechnology companies.

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With more than 30 years in the market place, the Kromasil product line is made by the Separation Products group, or the Kromasil team, a group of people with skills in a wide range of areas. We are dedicated to our mission to develop outstanding packing materials for HPLC/SFC/SMB, to improve efficiency and decrease costs in your separation step.

When the first Kromasil silica-based packing materials were introduced in the market, they greatly improved the effectiveness of liquid chromatography. What made the new packing material so unique was the combination of high pore volume and surface area, together with a very high mechanical stability. Today this combination of properties is still unmatched by other chromatography packings on the market.