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Kromasil^® diC4 offers slightly different caracteristic than a classic C4 enabling oportunities to remove impurities from your peptide/protein crude.

Shipping in bulk in 10 and 13 µm particle sizes for 100 Å materials and 10 and 16 µm for 300 Å materials.

To learn more:

“This investment reflects Nouryon’s commitment to be a trusted partner to the pharma and biotech industries, which increasingly rely on us to provide solutions that contribute to the production of safe pharmaceuticals,” said Johan Landfors, Executive Vice President and President, Technology Solutions and Europe at Nouryon.

Kromasil products are used by the pharmaceutical, food and beverage, clinical, and environmental industries for applications ranging from laboratory analysis to industrial-scale purification. Kromasil contributes to improved treatment of diabetes as a vital part of the purification of insulin. Other uses include complex bio-pharma applications.

“Bio-pharmaceuticals, such as peptides, proteins and hormones, are a growing market and we see an increase in demand worldwide, particularly from our customers in India, China and Southeast Asia,” said Patrick Wilhelm, Vice President of Inorganic Specialties at Nouryon. “This facility expansion will reinforce our leadership position in the global high-performance silica market targeted to the pharma and biotech industries, and it will allow us to meet the growing demand for our Kromasil products.”

Construction of the Nouryon facility expansion is scheduled to begin in 2022.

Nouryon is a leading producer of high-performance silica worldwide and has more than 30 years of expertise in spherical silica for analytical to process-scale liquid chromatography under the brand Kromasil. Kromasil chromatography resins offer superior separation performance leading to increased efficiency and decreased costs.

This investment follows Kromasil’s recently introduced efficient purification strategy for GLP-1 agonists used for type 2 diabetes.

Media release on the Nouryon website

“With our efficient purification strategy, it is possible to reach the 99.5 % purity needed for regulatory approval in only two steps compared to three or four steps, which is often the case in the industry today. This translates into greatly improved efficiency and productivity for our customers, said Patrick Wilhelm,” Vice President of Inorganic Specialties at Nouryon.

The new purification toolbox for GLP-1 (glucagon-like peptide-1) agonists such as liraglutide, enables tailor made solutions to the different conditions in our customers production processes and includes procedures that greatly improve the Kromasil media lifetime by increasing the number of purification cycles that can be carried out. This enables our customers to significantly reduce the time needed to optimize their purification process and as a result, a more efficient process.

“Type 2 diabetes patients rely on their medicine every day and, in many cases, it’s a lifelong treatment. We are proud to be able to provide our pharmaceutical customers with solutions that contribute to the promotion of well-being to ensure healthy lives,” said Wilhelm.

To learn more, download our brochure, listen to how our scientists talk about it or get in touch with us:

Kromasil C18(w) is part of the Kromasil Classic portfolio of perfectly spherical, totally porous silica media with 100 Å pore size. The phase, with its polar embedded end-capping, has different characteristics than the classic Kromasil C18, as is shown in the comparing Tanaka diagram. This allows for separations and analysis of samples that are naturally provided in aqueous conditions. The new wettable phase enables new selectivity and resolution opportunities to isolate impurities and enrich samples containing compounds such as amino acids and peptides. The chromatography can be run under RP conditions or in fully aqueous conditions if required.

The Kromasil wettable phase is now supplied in both 5 and 10 µm particles. Columns are available from 4.6 to 21.2 mm ID. The larger particles are also available as bulk for packing in DAC systems – even repeatedly, as the well-known mechanical stability of Kromasil packing media is also valid for this material.

Independently, if you work with analysis, development or screening, in pilot facilities or manufacturing, the flexibility and alternative selectivity offered by Kromasil C18(w) can be of significant benefit for your facility in view of the wider spectrum of polar compounds that are currently investigated and purified in pharma and biotechnology companies.

With more than 30 years in the market place, the Kromasil product line is made by the Separation Products group, or the Kromasil team, a group of people with skills in a wide range of areas. We are dedicated to our mission to develop outstanding packing materials for HPLC/SFC/SMB, to improve efficiency and decrease costs in your separation step.

When the first Kromasil silica-based packing materials were introduced in the market, they greatly improved the effectiveness of liquid chromatography. What made the new packing material so unique was the combination of high pore volume and surface area, together with a very high mechanical stability. Today this combination of properties is still unmatched by other chromatography packings on the market.

Untill end of year 2019, you can benefit from attractive prices on selected Kromasil columns with small particles for UHPLC. Read more on the campaign page and contact your local distributor for the best offer.

The new Kromasil wettable phase is the latest innovation of Nouryon on the chromatography market, and a further expansion of the Kromasil Classic portfolio. It is an end-capped phase, permits sample loading and run start in 100% aqueous. Kromasil 100 Å C18 (w) is supplied in 10 µm particles as bulk and packed columns from 4.6 mm ID to 21.2 mm ID.

Independently, if you work in development or screening, pilot facilities or manufacturing, the alternative selectivity offered by Kromasil 100 Å 10 µm C18 (w) can be of significant benefit for your facility in view of the wider spectrum of polar compounds investigated and purified in pharma and biotechnology companies.

With more than 30 years in the market place, the Kromasil product line is made by the Separation Products group, or the Kromasil team, a group of people with skills in a wide range of areas. We are dedicated to our mission to develop outstanding packing materials for HPLC/SFC/SMB, to improve efficiency and decrease costs in your separation step.

When the first Kromasil silica-based packing materials were introduced in the market, they greatly improved the effectiveness of liquid chromatography. What made the new packing material so unique was the combination of high pore volume and surface area, together with a very high mechanical stability. Today this combination of properties is still unmatched by other chromatography packings on the market.

Untill end of June 2019, you can benefit from attractive prices on selected Kromasil 21.2 mm semi-prep columns. Read more on the campaign page and contact your local distributor for the best offer.

Whatch the full story (2:26 min) on YouTube:

Other movies about Kromasil^® products can be found on the movies page.

The former AkzoNobel Specialty Chemicals is today being relaunched as Nouryon. The move follows the recent acquisition of the business by The Carlyle Group and marks the company’s transition to becoming an independent, global specialty chemicals leader.

Kromasil will sustain its commitment to deliver its products to the market under the new company name as we have for the last 30 years.

We are pleased to announce the expansion of the Kromasil SFC platform of chromatographic columns to continue our worldwide support for research, discovery and compound isolation with Supercritical Fluid Chromatography (SFC). These Kromasil SFC columns are now shipping in cyano, diol, silica, 2-ethylpyridine and organo-silane chemistries to give users more options to separate and purify a wide range of substances, from non-polar to strongly polar compounds, including small synthetic molecules and peptides.

Kromasil diC4 offers slightly different characteristic than a classic C4 enabling opportunities to remove impurities from your peptide/protein crude.

Now shipping in bulk in 10 and 16 µm particle sizes.

Kromasil EternityXT C8 consists of silica particles used for purification of compounds that can be run under a wide range of pH. The product was already made available in bulk for large-scale applications and is now introduced in new convenient pre-packed columns which are suited for small-scale testing and analysis. The columns are available in three particle sizes: 1.8 μm for UHPLC applications, 2.5 μm for both UHPLC and HPLC applications and 5 μm for HPLC and semi-preparative chromatography.

We are pleased to announce that Kromasil EternityXT 10 μm C8 bulk material is now shipping. Kromasil EternityXT 10 μm materials are used in reversed phase chromatography, they are end capped and now delivered in both C18 and C8 derivatizations, providing the flexibility needed for small, medium and large scale preparative chromatography. This family of Kromasil EternityXT stationary phases supports scientists and engineers working in purification under extreme harsh conditions that may be challenging to the mechanical and chemical stability of the stationary phase.

We are pleased to announce our next expansion of the analytical columns portfolio with the introduction of Kromasil EternityShell columns.

Kromasil EternityShell columns are a further expansion of the Kromasil analytical portfolio. Kromasil EternityShell columns have been designed for users who expect to perform separations between pH 1 and 12 and look for fast separations using solid-core technology.

We are pleased to announce our next expansion of the analytical columns portfolio with the introduction of Kromasil ClassicShell family of columns.

The new Kromasil ClassicShell columns offering is based on solid core particle technology to give researchers and analysts an alternative to their chromatographic separations.

We are proud to present our new compilation of SFC columns. These are based on our reputated 100 Å spherical silica in 2.5 µm particle size technology for reliability and efficiency in supercritical fluid chromatography.

Kromasil presents the last addition to it's UHPLC and HPLC assortment of columns. These new columns are based on our state-of-the-art manufacturing of chemically stable phases for wide pH-range usage.

AkzoNobel is pleased to announce its new range of Kromasil UHPLC columns with 1.8 μm particles with the highest efficiency for laboratory analysis.

Separation Products is proud to present its new preparative product, EternityXT, based on a patent-pending grafting technology, where further development of the Eternity technology has produced a material with an extended lifetime even under extremely demanding conditions.

Kromasil Eternity was introduced a few years ago, for analytical HPLC. Kromasil EternityXT is an extension of the Eternity portfolio, introducing a 10 μm C18 product aimed at preparative applications run under extreme conditions.

The pH window where EternityXT can be used is from 1 to 12, giving more flexibility than ever when optimizing for large-scale applications.

We are pleased to announce the new Kromasil columns with 2.5 μm particles and provide researchers worldwide with reliable 2.5 μm based columns for their laboratory analysis in HPLC / UHPLC.

We are pleased to celebrate the 25 years of Kromasil, the high performance chromatographic media based on state-of-the-art spherical silica for analytical and industrial HPLC applications. Initially sold for the purification of insulin, Kromasil is now the premium choice for pharmaceuticals and API purifications worldwide for its outstanding mechanical and chemical stability, consistent batch-to-batch reproducibility and extraordinary selectivity.

Eka Chemicals AB has for many years been a business unit of the chemical, paints and industrial coatings group AkzoNobel. As from December 1^st, 2012 we have changed our legal entity name Eka Chemicals AB to Akzo Nobel Pulp and Performance Chemicals AB. The new name reflects a change in our business strategy, implemented to strengthen our business for the future. Please note that we will not change our organization VAT number - we have only changed the registered name of our legal entity.

Kromasil is a brand developed and marketed by Separation Products, a group within the business unit AkzoNobel Pulp and Performance Chemicals.

Separation Products moves its China office to the AkzoNobel site of Songjiang near Shanghai. Equipped with its own laboratory, Separation Product will be able to expand and enhance its technical support to customer in China and surrounding countries.

The new address can be found on the contact page

Kromasil HILIC-D is designed for the best selectivity of polar compounds. This diol derivatized phase provides excellent reproducibility when compared to HILIC columns based on standard bare silica. Kromasil HILIC-D offers a robust column that is 100% MS compatible. The phase is low bleed and the solvents used when running your HPLC in HILIC mode are optimal for MS. Therefore the sensitivity can be 100 times better when using Kromasil HILIC-D over traditional reversed phase columns.

For additional information:

Beijing, China

Separation Products arranged a conference on preparative and process chromatography in Beijing, China, 27-29 October, 2010. This conference was the 6th in a series of well-attended and much appreciated chromatography conferences and workshops organized since 2002 by Separation Products. The conference was held on the outskirts of Beijing, in the Chateau Laffitte Hotel, with nice surroundings, and a hotel looking like a French castle!

About 70 people from 38 different companies and universities attended the conference, and over the three days, 17 talks and four workshops were given. The subjects ranged from drug discovery, chiral separations, and large scale application examples to equipment and packing material design, making the program useful and interesting to most everyone attending.

In addition to the scientific program an excursion to the Great Wall and the Ming Dynasty Tombs was arranged, giving all the possibility to see some of China?s biggest attractions during the visit to Beijing.

The very positive feedback from the attendees gives us courage to start already now to plan for our next conference in this series. Information on where and when will be forwarded to our friends in the prep HPLC community later on!

At HPLC 2010 in Boston (MA, USA), we proudly present a new member to our Eternity family of chemically stable phases for wide pH-range usage.

Kromasil Eternity PhenylHexyl is a fully wettable phase with alternative selectivity compared to the C18 phase of the family, expanding the action field for demanding separations in a wide pH-range.

Get the presenting folder at our exhibition stand or download it now as a pdf from this site with the link below.

From May 31 to June 2, Separation Products held a conference on the subject of preparative chromatography. The conference was held at Säröhus, south of Gothenburg and customers from all over the world and representatives from a variety of Universities were invited to attend and give talks.

The conference attracted guests from 27 different companies and six universities, in addition to employees from Kromasil in the US, China and Sweden. In total, 69 people took part in the event, which, despite a packed program, also gave participants the opportunity to enjoy the beautiful archipelago off the western coast of Sweden.

The conference program was intensive, with 22 talks over one and a half days. In addition to this, the group managed to take in a highly appreciated boat tour of the archipelago in fantastic weather.

We have already received praise that the conference was both educational and extremely enjoyable, it gave a lot of opportunities to make new contacts with colleagues from other companies in the same business area. So, we have already decided to arrange a similar conference in China in 2010 and another on the west coast of Sweden in 2011.

From Pittcon 2009, Chicago, IL, USA

Separation Products is proud to present its new analytical platform Eternity, a new organosilane merged silica with high chemical stability in a wide pH range. This makes Kromasil Eternity an ideal choice for method development for ionic substances where pH is an important factor for optimizing selectivity.

Kromasil Eternity is available in as small particles as 2.5 ?m, enabling high resolution on short columns, qualifying for time and eluents savings.

Visit the website, or download the pdf information folder:

Location: Särö, Sweden

Date: June 1-2, 2009

Separation Products arranges a conference and workshop for preparative and process scale chromatography in Särö, Sweden. Conference topics include chiral separation, new ideas in drug discovery, process equipment and operation, modeling and simulation.

Contact us for an invitation!

Taking reversed phase chiral separation to a new level, Separation Products launches new members to it's popular coated phase chiral products family. Enjoy the high efficiency and resolution of the unique 3 µm particles on your analytical RP separations.

Check for more info and applications on the respective flyer in the publications section:

Kromasil is a premium silica-based packing material developed for Preparative, Process and Analytical HPLC, SFC and SMB.

Kromasil analytical and preparative columns for Normal Phase, Reversed Phase and Chiral Phase liquid chromatography have been available worldwide as original columns from AkzoNobel, or via independent column packers in different countries.

In order to secure the quality and supply of our columns, Kromasil has decided to take full responsibility for all manufacturing steps from silica to column packing. From January 1st 2008, Kromasil have stopped the sales of analytical bulk material to independent column packers. Following the new analytical strategy we also establish a network of more dedicated distributors of Kromasil original columns worldwide. Kromasil original columns will only be available directly from us, or from our network of distributors.

Separation Products is launching the new Kromasil AmyCoat chiral phase at CHIRALITY 2007, San Diego, CA, USA July 8-11, 2007.

In order to meet the growing demand for service and presence toward HPLC customers in China, a new Separation Products office has been opened in Beijing for a closer contact channel with Kromasil customer and distributors.

The Kromasil website has undergone a total layout remake. New functions has been added:

• Online application Guide
• Product selection tool

Separation Products is launching the new Kromasil CelluCoat chiral phase at CHIRALITY 2006 Busan, Korea, June 25-28, 2006.

Separation Products, a sector within Eka Chemicals AB, is implementing a new strategy by strengthening its distribution and sales channels for Kromasil analytical products.

The list of authorized Kromasil column distributors is shown on our website. Please find the press release from the General Manager.

From February 2006 it is possible for all Kromasil users to order standard Kromasil columns online. After registration as an E-customer you will access the online store with prices in the correct currency for your country, and can place your order conveniently and instantly.

Please find the Online Store at http://www.kromasil.com/online/

As of 1 July 2005 GE Healthcare Amersham Biosciences K.K. has been appointed the sole distributor of Kromasil in Japan. Amersham Biosciences have established a strong marketing and sales network in Japan, which will ensure an efficient distribution network for Kromasil media and columns in the country.

Please find a press release regarding the agreement between the companies in English and Japanese!

Separation Products is launching the new Kromasil Diol phase at PittCon 2005 in Orlando February 27 - March 4. The Diol phase has been developed in order to provide excellent performance in both HPLC as well as in SFC. Kromasil Diol shows unique characteristics, and provides an alternative selectivity in both NP and RP mode.

Separation Products is launching the new Kromasil Phenyl phase at PittCon 2005 in Orlando February 27 - March 4. Kromasil Phenyl is developed to be the perfect alternative to present Kromasil phases. The phase is completely wettable, and compatible with 100% aqueous mobile phases. Kromasil Phenyl exhibits a unique selectivity for aromatic compounds, due to a possibility for - interactions between the phenyl bonded phase and the solute.

Separation Products has launched the long-awaited 48-page Kromasil Application Guide! The guide contains general guidelines how to make the best out of your Kromasil packing materials and columns, and a variety of chromatographic separations, from small synthetic pharmaceuticals, up to peptides and larger molecules.
We hope the guide will be a useful tool when developing new HPLC separation methods in your lab.

At HPLC2004, Separation Products introduced a new analytical brochure. The brochure contains information regarding important aspects of analytical HPLC, and several comparison studies between Kromasil analytical products and other leading analytical brands. Separation Products is, from now on, determined to focus much more on the analytical market.”