A nice scale-up example from column i.d. 4.6 to 21.2 mm.
Below are chromatograms illustrating the separation of fish oil esters on two Kromasil 100-10-C18 columns, 4.6 and 21.2 mm, respectively. On the two columns, both an analytical (left chromatogram) injection and an overloaded (right chromatogram) injection are performed.
The figures show a nice scalability from the 4.6 to the 21.2 mm columns. The scaling factor between the two columns is ~21 and the flow rates and loadings are scaled accordingly.
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