Kromasil HILIC-D is designed for the best selectivity of polar compounds. Traditionally, polar compounds like organic acids, nucleobases, and water soluble vitamins have been a challenge to separate on a standard reversed phase column like C18. Kromasil HILIC-D offers a phase that has true orthogonal selectivity when compared to a C18 column, normally giving an opposite elution order. The diol derivatized Kromasil HILIC-D provides excellent reproducibility when compared to HILIC columns based on standard bare silica.
In addition to the orthogonal selectivity, Kromasil HILIC-D offers a robust column that is 100% MS compatible. The phase is low bleed and the solvents used when running your HPLC in HILIC mode are optimal for MS. Therefore the sensitivity can be 100 times better when using Kromasil HILIC-D over traditional reversed phase columns.
When purifying polar compounds, Kromasil HILIC-D can be scaled up, offering the same great performance as in analytical scale. Take advantage of the generous surface area which can provide high loading capacity.
In recent years, there were animal and human deaths due to the contamination of food and milk products with melamine. The addition of melamine to food or milk containing cyanuric acid causes the production of melamine cyanurate which in turn creates kidney problems that can lead to death. Therefore the FDA has mandated that milk and prepared food be tested for melamine. Kromasil HILIC-D provides the proper selectivity and excellent MS compatibility to be able to analyze even the smallest amounts of melamine.
1: bare silica data
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