End capping describes the process of reacting silanol groups that have not been derivatized, e.g. octadecylchlorosilane. The end capping reagent is generally a smaller silane (e.g. trimethylchlorosilane) that is used to react with some of the residual hydroxyl groups. This treatment reduces the amount of available silanol groups that can undergo often undesired interactions with polar or charged analytes.
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