There is virtually none! Both the polysaccharide based CSPs Kromasil AmyCoat and CelluCoat, as well as the CSPs based on a crosslinked network polymer, Kromasil TBB and DMB, are based on highly mechanically stable, in-house produced, porous silica spheres. Moreover the proprietary coating method for the polysaccharide based phases makes these CSPs highly resistant to hydrodynamic forces. Thus, all Kromasil CSPs can be operated up to 400 bar back pressure. Exploiting the full pressure drop range of classical HPLC instruments allows for fast analysis and moreover very efficient column equilibration at high flow rates.
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